janubrim

janubrim

Topical brimonidine gel 0.33% with the brand name janubrim is produced for the first time in Iran by Zharf Andishan Navid Samet (Janus) and is used to treat erythema and redness caused by acne rosacea. This product has a knowledge-based certification from the Vice Presidency for Science and Technology.

janubrim
janubrim - Image 2

Introducing janubrim

The topical 0.33% brimonidine gel, marketed as Janu-Brim, was first produced in Iran by Zharf Andishan Navid Salamat (Janus) and is used to treat erythema and redness caused by acne rosacea. This product holds a Knowledge-Based Company certification from the Vice-Presidency for Science and Technology. Rosacea is a chronic skin condition typically characterized by erythema and inflammatory lesions in the central facial area. Although the exact pathophysiology is not fully understood, inflammation and vascular dysfunction appear to be key factors. Brimonidine is a selective alpha-2 adrenergic agonist with higher affinity for alpha-2 receptors than alpha-1. By constricting small arteries and veins, this drug can reduce patient erythema.

Key Points

  • Pregnancy and breastfeeding: Due to insufficient controlled studies, use during pregnancy and breastfeeding is not recommended; transfer to breast milk unknown.
  • Age: janubrim suitable for adults 18 and older; not recommended for children, prohibited under 2 years.
  • Contraindications: Do not apply on irritated skin or open wounds. Avoid contact with eyes and mucous membranes (mouth, nose).
  • Common side effects: Redness, itching, burning sensation on facial skin.
  • If severe effects occur: If rosacea worsens, skin irritation, hot or cold sensation, dry mouth, eyelid swelling, headache, local pain, dry skin, nasal congestion, or acne appear, stop use and consult doctor or pharmacist.
  • Precautions: Patients with cardiovascular, renal, hepatic diseases, depression, circulation problems in heart or brain, or Sjögren’s syndrome should consult doctor before use.
  • Drug interactions: If using MAO inhibitors, anesthetics, sedatives, narcotics, alcohol, beta-blockers, antihypertensives, or cardiac glycosides, consult doctor before use.
  • Storage: Store at room temperature below 25°C, protect from freezing.

janubrim Directions

Apply the medication once daily, using an amount the size of a pea, evenly as a thin layer on the forehead, chin, nose, and cheeks. The total daily amount should not exceed one gram (approximately pea-sized for the entire face).

Immediately wash your hands with water after application. If no improvement is observed after five days of use, consult your doctor or pharmacist.

Download janubrim Brochure

Download brochure

FAQ

  • Is worsening redness, especially in the first few days after using janubrim normal?
    Redness is a side effect of the drug and may appear in some individuals. If there is no response to the drug or allergic reactions occur, stop use and consult your doctor.
  • Does using janubrim cure rosacea or is it symptomatic treatment?
    No drug has been identified that permanently and definitively eliminates rosacea. janubrim gel is a symptomatic treatment to reduce and control facial redness.
  • What is the treatment duration with janubrim gel? Does redness return after stopping?
    Treatment duration is 8 weeks. Since efficacy is through vascular constriction, treatment is symptomatic and redness returns after stopping.
  • Can janubrim gel be used under creams and cosmetics?
    janubrim gel can be used half an hour before leaving the house, and after the gel dries, applying cosmetics, sunscreen, or moisturizer on the skin is permissible.
  • Is janubrim gel effective on effects caused by Demodex parasite?
    No. janubrim does not affect Demodex. However, patients with rosacea caused by Demodex can use janubrim under doctor supervision to control facial redness.
  • Is there information about resistance to janubrim after 1 to 2 months of use and lack of continued skin response?
    Treatment with janubrim is 8 weeks, no resistance reported during this period. Longer-term studies not conducted.
  • janubrim was accidentally exposed to direct sunlight, what should I do?
    If exposure to sunlight was less than one hour, despite reduced active ingredient effect, you can still use the product. Exposure more than one hour or inside a car in summer may destroy the formulation; it is better to obtain a new drug.
  • janubrim was accidentally placed in the freezer, what should I do?
    Unfortunately, the gel structure is damaged, purchase a new drug.
  • If the drug contacts lips and mouth, what should I do?
    Clean the area with a tissue and rinse the remaining drug thoroughly with water. Do not try to remove it by licking or swallowing.
  • If the drug contacts eyes, what should I do?
    Accidental contact of janubrim gel with eyes causes moderate inflammation and itching. After contact, do not rub eyes and immediately rinse eyes with plenty of water for at least 15 minutes. During rinsing, open and close eyes repeatedly to ensure adequate washing. If eye irritation persists, consult a doctor.
  • If the drug is inhaled, what should I do?
    Since the drug is topical, inhalation is very unlikely. If inhaled, move the patient to fresh air to breathe.
  • The drug was ingested by the patient, what actions should I take?
    If ingested, immediately give large amounts of water or milk to dilute the active ingredients. Then go to the hospital immediately. Do not induce vomiting. Oral ingestion of brimonidine has severe side effects and should not delay visiting a doctor.
  • What side effects may occur if ingested?
    Serious side effects from ingesting topical janubrim gel include breathing disorders, severe dizziness, decreased heart rate, diarrhea and vomiting, fainting, severe itching and swelling.
  • How long is the drug usable after opening?
    If stored under conditions stated on the box, usable up to 90 days. At the end of 90 days, by checking color, odor, and consistency, stability of janubrim can be somewhat assured. However, the product weight is such that with normal use, it is typically finished in less than 90 days after opening.