The topical solution of diphenyl cyclopropenone, also called diphencypron, is a topical treatment of alopecia areata.
Alopecia areata: It is a sudden hair loss in a circular area on the head with a clearly defined margin, with no visible evidence on the scalp. Alopecia areata is one of the autoimmune diseases in which lymphocytes around the hair follicle release chemical messengers that inhibit hair growth for unknown reasons. And is mostly resistant to treatment. The disease can also involve eyebrows, eyelashes, genital and even whole hair of the hands and feet. These areas may be single or multiple. In rare cases, hair loss may be complete. There is no pain at the site of the lesion, and the skin is completely normal and smooth. Alopecia areata treatment includes topical and injectable corticosteroids, as well as chemical treatments such as diphencypron and dinitrochlorobenzene topical solutions.
Mechanism of action: Its mechanism of action is the sensitization of the skin cells, which then activates the immune system, and the white blood cells distract from the hair follicle and divert to the stimulated region. Reports have shown that in more than 50% of the People who have used this drug have been satisfied with hair growth.
Dosage form: Topical solution at 2%, 1%, 0.5%, 0.1%, 0.05%, 0.01%, 0.001%, and 0.02% concentration in borosilicate glass vials of brown color type1 is packed individually.
Session 1: Sensitize the patient with the highest dose of treatment. A small skin patch is placed in the lesion site and is removed after 24 hours to induce allergic reaction in the individual. In this area, for 3 to 5 days, the person has a pruritus. The target area should not be exposed to direct sunlight.
Session 2 (2 weeks after the first session): If the patient shows a severe reaction to the drug, it means that he has responded to this drug. In this session, the lowest concentration of the drug starts on the patient’s arm and is tested for 24 hours to achieve the appropriate treatment dose (with signs of allergy). Normally, every week, administration of the appropriate doses in the affected area continues and after 2 days the area is washed.
Side effects: Usually safe and has no side effects. Redness, blistering, itching and white spots are due to the usual side effects of taking this medication.
Storage condition: Keep at temperatures below 30 ° C and away from direct sunlight.
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- DCP therapy for alopecia areata. Patient information Sheet, Skin and Cancer Foundation Australia, 277 Bourke Street, Darlinghurst, NSW, Australia.
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